Spedra

What makes Spedra special?

Spedra (avanafil) is the newest erectile dysfunction medication in the PDE-5 inhibitor class. The active ingredient in Spedra, avanafil, was specifically developed to offer two key advantages: the fastest onset of action and exceptionally high selectivity, making it a popular choice for men looking to buy Spedra online.

The fastest onset of action: Unlike older medications that take 30–60 minutes, Spedra can start working in as little as 15-30 minutes—and some users report improvements from about 12 minutes. This makes it ideal for men seeking increased spontaneity.

High selectivity and good tolerability: Avanafil was developed to be highly selective for the PDE-5 enzyme in the penis. This means less impact on other phosphodiesterases in the body and potentially fewer side effects from Spedra compared to older PDE-5 inhibitors.

Balanced duration of action: Spedra’s effect lasts up to 6 hours, long enough for natural flexibility without the prolonged action of medicines like Cialis

Spedra in focus

Dosages	50 mg, 100 mg and 200 mg
Recommended starting dose	Spedra 100 mg
Maximum dose	Spedra 200 mg
Dose timing	15 - 30 minutes before sexual activity
Effect duration	Up to 6 hours
Condition	Requires sexual stimulation
Minimum interval between doses	24 hours
Taking with food	Can be taken independently of meals, but avoid very high-fat meal
Spedra with alcohol	Avoid excessive alcohol consumption

How does Spedra work?

Spedra belongs to the PDE-5 inhibitor class. Its active ingredient, avanafil, blocks the PDE-5 enzyme that breaks down cGMP, a messenger responsible for relaxing blood vessel walls in the penis.

During sexual stimulation, nitric oxide increases cGMP production. By inhibiting PDE-5, Spedra helps cGMP remain active longer, allowing better blood flow into the erectile tissue and supporting firmer erections.

Important: Spedra tablets only work with sexual stimulation and do not increase libido.

Is Spedra available without a prescription?

No, Spedra is available only on prescription. It is not legal to buy avanafil without a prescription. A doctor's assessment ensures that the medication is suitable for you, that there are no dangerous interactions, and that the dosage is correct. This also applies if you wish to buy Spedra online.

Depending on your prescribed strength, you can buy Spedra 50 mg, buy Spedra 100 mg or buy Spedra 200 mg, allowing your doctor to tailor the treatment to your individual response and level of erectile dysfunction.

Who is Spedra suitable for?

Spedra is suitable for adult men with erectile dysfunction who value rapid onset of action and spontaneity. It is particularly advantageous to order Spedra for:

• Men who desire spontaneity: The rapid onset of action after 15-30 minutes allows for spontaneous sex without long waiting times.
• First-time users of ED meds: Spedra's good tolerability due to high selectivity makes it a good choice for men trying ED treatments for the first time.
• Patients with side effects from other erectile dysfunction medications: Men who have experienced bothersome side effects such as visual disturbances or nasal congestion with other PDE-5 inhibitors often tolerate Spedra better.
• Men with occasional erectile dysfunction: The duration of action of up to 6 hours is ideal for occasional use without an excessively long effect.

However, before ordering Spedra, you should always consult a doctor to determine whether:

• Cardiovascular diseases are present
• Other medications are being taken
• Severe liver or kidney disease exists
• An allergy to avanafil or other ingredients is present.

How to take Spedra correctly?

Recommended dosage of Spedra:

The standard dose is 100 mg of avanafil approximately 15 to 30 minutes before sexual activity. Depending on effectiveness and tolerability, the dose may be adjusted by increasing to 200 mg or lowering to 50 mg. 

Important notes:

• Take Spedra tablets at most once a day
• A minimum interval of 24 hours between doses must be observed.
• Swallow the tablet whole with a glass of water.
• It can be taken regardless of meals.
• For optimal effectiveness of Spedra: Avoid very fatty meals immediately before taking it.
• When taken on an empty stomach: Fastest onset of action possible after 15 minutes.

Avoid overdosing: Exceeding the recommended maximum dose of Spedra 200 mg does not lead to better results, but significantly increases the risk of Spedra side effects.

When should Spedra not be taken?

You should not buy or take Spedra if you:

• are allergic to avanafil or any other ingredients in the medication
• are taking nitrates or nitric oxide donors (e.g. for angina pectoris)
• are taking guanylate cyclase stimulators such as riociguat
• Taking strong CYP3A4 inhibitors such as ketoconazole, itraconazole, ritonavir, indinavir, saquinavir, nelfinavir, atazanavir or clarithromycin
• Severe cardiovascular disease or recent heart attack or stroke (within the last 6 months)
• Uncontrolled high blood pressure or very low blood pressure (below 90/50 mm Hg)
• Severe liver failure (Child-Pugh class C)
• Severe renal impairment with creatinine clearance below 30 ml/min
• Previous vision loss due to non-arteritic anterior ischaemic optic neuropathy (NAION)
• Congenital degenerative retinal disorders

Spedra is not approved for women or persons under the age of 18.

What side effects can occur with Spedra?

Frequently (up to 1 in 10)	headache, flushing, nasal congestion
Occasionally (up to 1 in 100)	dizziness, tiredness, sinus congestion, back pain, rapid heartbeat, palpitations, indigestion, nausea, blurred vision, raised liver enzymes
Rarely (up to 1 in 1,000)	allergic symptoms, chest pain, high blood pressure, abdominal pain, diarrhoea, genital itching, spontaneous erections without stimulation, swelling of feet/ankles, blood in urine, abnormal PSA or creatinine levels, fever, nosebleeds

Most Spedra side effects are mild and short-lived.

Seek immediate help if you experience:

• erection lasting >4 hours (priapism)
• sudden vision or hearing loss
• severe chest pain 
• allergic reactions with swelling

A complete list is available in the package leaflet.

Which medications are incompatible with Spedra?

Avoid combining Spedra with:

• Nitrates & NO-donors – dangerous drop in blood pressure
• Strong CYP3A4 inhibitors – significant increase in avanafil levels
• Moderate CYP3A4 inhibitors (e.g., erythromycin, grapefruit juice) – limit to max. Spedra 100 mg, 48-hour spacing
• Alpha-blockers – risk of hypotension unless stable on therapy
• Other erectile dysfunction medications – never mix PDE-5 inhibitors
• Excessive alcohol – can worsen dizziness/headache

Important: Always inform your doctor about all medications you are taking – including over-the-counter medications and herbal preparations.

Experiences with Spedra

Many men report fast onset and good tolerability with Spedra tablets:

‘Spedra works much faster than Cialis or Viagra – and seems to cause fewer side effects, at least for me!’ (arznei-news.de)

However, some men experience insufficient effect:

‘Avanafil didn't work for me. I took it, waited and waited, but I never got an erection, so honestly, it didn't do anything for me at all.’ (drugs.com )

If Spedra is ineffective, a doctor may recommend alternative treatments or a full ED assessment.

Where to buy Spedra safely in the UK?

At the local pharmacy:

With a valid doctor's prescription, you can buy Spedra from any licensed pharmacy. You will also receive personalised advice on dosage and administration.

Online with medical check-up:

You can also buy Spedra online through a reliable healthcare platform. If you meet the requirements, you will receive an e-prescription and the medication will be conveniently delivered to your home.

Warning about dubious offers:

Websites advertising with claims like " Buy Spedra without a prescription " are operating illegally. Such products may be counterfeit, ineffective, or even harmful to your health.

How much does Spedra cost in the UK?

The price of Spedra depends on the dosage and pack size.

Tip: Larger packs often offer better value per tablet.

Further information

Package leaflet for Spedra 50 mg, 100 mg and 200 mg for download.