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What is Tadalafil?
Tadalafil is the active ingredient found in the erectile dysfunction medicine Cialis. When the patent for Cialis expired, other pharmaceutical companies were permitted to manufacture generic tadalafil. Tadalafil contains the same active ingredient at the same strength as Cialis and therefore provides the same therapeutic effect at a lower cost.
Tadalafil in focus
|
Dosages |
10 mg and 20 mg |
|
Recommended starting dose |
10 mg |
|
Maximum dose |
20 mg |
|
Dose timing |
30-60 minutes before sexual activity |
|
Effect duration |
4-6 hours |
|
Condition |
Requires sexual stimulation |
|
Minimum interval between doses |
24 hours |
|
Taking with food |
With or without food. Avoid grapefruit |
|
Tadalafil and alcohol |
Only small amounts recommended (1–2 drinks) |
How does Tadalafil work?
Tadalafil belongs to the group of PDE-5 inhibitors, just like Sildenafil, Vardenafil and Avanafil.
Tadalafil inhibits the enzyme PDE-5, so that the messenger substance cGMP remains active in the penis for longer – this keeps the blood vessels dilated, which allows for a stronger and longer-lasting erection during sexual arousal.
|
Onset of action |
Duration of effect |
|---|---|
|
After 30 to 60 minutes |
Up to 36 hours |
The exceptionally long duration is what distinguishes tadalafil from sildenafil or vardenafil. However, like all ED medicines, tadalafil only works in the presence of sexual stimulation.
How to buy Tadalafil in the UK?
Tadalafil is a prescription medication. This applies to both Cialis and all generic Tadalafil products. To buy tadalafil, consult a doctor who will determine whether the treatment is appropriate and safe.
This also applies if you want to buy Tadalafil online in the UK. Reputable healthcare platforms where you can order Tadalafil online always require a medical consultation before prescribing it.
Buying tadalafil online from non-verified websites increases the risk of counterfeit medicines, which may be ineffective or dangerous.
How to take Tadalafil pills correctly?
- Take tadalafil pills with a glass of water 30–60 minutes before sexual activity
- Take no more than one dose in 24 hours
- Do not exceed the maximum dose of tadalafil in 24 hours – 20 mg
- Sexual stimulation is required for the medicine to work
Avoid common mistakes:
- Taking tadalafil too soon before intercourse
- Heavy alcohol consumption
- No sexual stimulation
- Self-medicating or attempting to buy tadalafil over the counter
Contraindications for Tadalafil
You must not order Еadalafil or take it if you:
- are allergic to tadalafil
- use nitrates or nitric oxide donors (risk of severe hypotension)
- have had a heart attack within the past 90 days
- have had a stroke within the past 6 months
- have very low or uncontrolled high blood pressure
- have had vision loss due to NAION (“eye stroke”)
- take riociguat
- take strong CYP3A4 inhibitors (ketoconazole, ritonavir, clarithromycin)
- take CYP3A4 inducers (rifampicin, carbamazepine), which reduce effectiveness
- have conditions predisposing to priapism (sickle cell disease, multiple myeloma, leukaemia)
What side effects can occur with Tadalafil?
Common Tadalafil side effects include:
Headache, back pain, muscle pain, pain in the arms and legs, facial flushing, nasal congestion, indigestion or reflux.
Seek immediate medical attention if you experience the following symptoms:
- Priapism (erection lasting more than 4 hours)
- Sudden loss of sight or hearing
- Chest pain during/after sexual intercourse
- Allergic reactions (swelling, shortness of breath)
- Severe dizziness or fainting (can indicate dangerously low blood pressure).
Most of the side effects are mild and temporary. No long-term side effects of tadalafil have been observed.
The lower the dosage of Tadalafil, the lower the risk of side effects and the shorter their duration.
For detailed safety information, refer to the official package leaflet.
Taking Tadalafil pills with other medicines
Tadalafil may interact with some other medicines.
You must not take tadalafil with nitrates.
Special care should be taken with the following medicines:
- Alpha blockers
- Other medicines for treating high blood pressure
- Riociguat
- 5-alpha reductase inhibitors
- Ketoconazole and protease inhibitors
- Phenobarbital, phenytoin and carbamazepine
- Rifampicin, erythromycin, clarithromycin or itraconazole
- Other medicines used to treat erectile dysfunction
Experiences with Tadalafil
Tadalafil impresses many users with its long duration of action and good tolerability.
“Had trouble keeping fully erect, talked with doctor and started with 20 mg. Takes about 15 to 20 minutes to kick in, then lasts a day and a half. Wife is back to being fully satisfied and having sex several times a week. She loves the fact it increases circulation, as even if I’m limp, it appears bigger and longer, which gets her aroused more easily. No side effects unless you count a smile on your wife’s face." (drug.com)
Although some men report negative experiences with Tadalafil due to side effects, they say that the effect on erections is worth it.
“I take 10 or 20mg as needed. I have a lot of flushing and feel achy the next day plus I experience pretty bad indigestion. I take aspirin and antacids to get through it. The side effects are well worth it as I tend to have marathon "sessions" after taking it." (healthunlocked.com) |
Further information
Package leaflet of Tadalafil 10mg for download.
Package leaflet of Tadalafil 20mg for download.