Priligy (Dapoxetine)

What is Priligy?

Priligy is a prescription medicine containing dapoxetine, a fast-acting SSRI specifically developed to treat premature ejaculation. Unlike traditional antidepressants, dapoxetine tablets act rapidly and clear from the body quickly, making them ideal for on-demand use.

Because it is fast-acting and short-lived, Priligy tablets are taken only when needed.

Priligy in focus

Dosages	Priligy 30 mg (recommended starting dose); 60 mg (maximum dose – only if 30 mg is insufficient and well-tolerated)
Dose timing	1–3 hours before intercourse
How long does Priligy last?	Up to 4 hours from onset
Food & alcohol	Can be taken with or without food; Avoid excessive drinking (combining Priligy and alcohol increases risk of fainting, dizziness); Avoid grapefruit juice within 24 hours before taking the medicine
Minimum interval	One dose per 24 hours

How does Priligy work?

Sexual stimulation triggers brain signals involved in arousal, orgasm and ejaculation. Men with premature ejaculation often have increased sensitivity in this pathway.

When used for premature ejaculation, Priligy (dapoxetine) increases serotonin levels in key areas of the brain, delaying the ejaculatory reflex and improving control.

This results in:

• 2–3 times longer time to ejaculation
• Better control over ejaculation
• Reduced distress and better sexual satisfaction

Priligy tablets work only on ejaculation control – they do not treat erectile dysfunction.

How to buy Priligy in the UK?

Priligy is a prescription-only medicine.

To buy dapoxetine in the UK, you must complete a medical assessment with a doctor or an online healthcare provider.

• To buy Priligy online, a clinician reviews your questionnaire and issues a prescription if suitable.
• It is not legal or safe to buy Priligy tablets over the counter in the UK.
• Offers to provide Priligy over the counter or without a prescription should be avoided – they may involve counterfeit medicines.
• The price of Priligy in the UK varies depending on the supplier, the dosage, and the package size. The price of a 3-tablet 30 mg dapoxetine pack ranges from £20. Ordering Priligy online entitles you to discounts and special offers.

How to take Priligy tablets correctly?

Standard dose:

Priligy 30 mg, taken 1–3 hours before intercourse

If insufficient:

A doctor may increase to 60 mg

How to take:

• Swallow whole with water
• Do not take more than one dose in 24 hours
• If you tend to feel nauseous, avoid taking it on an empty stomach
• Limit alcohol — combining Priligy and alcohol increases the risk of dizziness and fainting

Common usage mistakes:

• Taking two doses too close together
• Combining with recreational drugs (“poppers”, stimulants)
• Using with certain antidepressants or mood medications
• Taking without sexual activity planned

For the safest use, follow medical instructions about Priligy dosage precisely.

Contraindications – who should not take Priligy?

Do not take Priligy pills if you:

• have a history of fainting or unstable blood pressure
• have heart rhythm disorders
• take SSRIs, SNRIs, MAOIs, or lithium
• use recreational nitrates (“poppers”)
• take strong CYP3A4 inhibitors (ketoconazole, ritonavir)
• have severe liver disease
• are under 18 or over 64
• are a woman (Priligy is tested and approved only for men; safety and effectiveness in women are not established).

Use with caution if you have:

• mild–moderate liver issues
• history of seizures
• bipolar disorder
• bleeding disorders

Always check with a doctor before taking dapoxetine pills.

What side effects can occur with Priligy?

Common Priligy side effects include:

• Nausea
• Dizziness
• Headache
• Insomnia
• Diarrhoea
• Feeling jittery or restless

Less common:

• Fainting
• Anxiety
• Sweating
• Increased blood pressure

Seek medical attention immediately if you experience:

• Severe dizziness or blackouts
• Chest pain
• Sudden mood changes
• Seizures

Most side effects are mild and temporary. Report any severe reaction to your doctor.

Taking Priligy with other medicines

You must not combine Priligy with:

• SSRIs, SNRIs, MAOIs, tricyclic antidepressants
• Lithium
• Thioridazine
• Tramadol (risk of seizures)
• Strong CYP3A4 inhibitors (ketoconazole, ritonavir, clarithromycin)
  • Other premature ejaculation treatments
• Recreational nitrates / poppers

Use caution with blood pressure medicines and recreational drugs.

Experiences with Priligy

Men treated with Priligy generally report improved control, reduced anxiety and longer lasting sexual activity. 

Some men experience side effects from Priligy such as dizziness or nausea, especially during the first doses or when taken on an empty stomach:

“Priligy works for me, but I always get about half an hour of stomach ache after I take it. Once the stomach ache clears up, you're good to go. I'd try taking it again not on an empty stomach and see if it improves.” Reddit

Further information

Package leaflet for Priligy (dapoxetine) for download.